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ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-β copathology
INTRODUCTION: Apolipoprotein E (ApoE) is the most important genetic risk factor for Alzheimer's disease (AD), with ApoE4 thought to enhance and accelerate amyloid-β (Aβ) pathology. ApoE4 has recently been described to increase neurodegeneration in a mouse model of frontotemporal dementia (FTD),...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430720/ https://www.ncbi.nlm.nih.gov/pubmed/30949567 http://dx.doi.org/10.1016/j.dadm.2019.01.010 |