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Water on hydrophobic surfaces: mechanistic modeling of polyethylene glycol-induced protein precipitation

For the purification of biopharmaceutical proteins, liquid chromatography is still the gold standard. Especially with increasing product titers, drawbacks like slow volumetric throughput and high resin costs lead to an intensifying need for alternative technologies. Selective preparative protein pre...

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Detalles Bibliográficos
Autores principales: Großhans, Steffen, Wang, Gang, Hubbuch, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430756/
https://www.ncbi.nlm.nih.gov/pubmed/30535587
http://dx.doi.org/10.1007/s00449-018-2054-5