Overcoming the thermodynamic equilibrium of an isomerization reaction through oxidoreductive reactions for biotransformation

Isomerases perform biotransformations without cofactors but often cause an undesirable mixture of substrate and product due to unfavorable thermodynamic equilibria. We demonstrate the feasibility of using an engineered yeast strain harboring oxidoreductase reactions to overcome the thermodynamic lim...

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Detalles Bibliográficos
Autores principales: Liu, Jing-Jing, Zhang, Guo-Chang, Kwak, Suryang, Oh, Eun Joong, Yun, Eun Ju, Chomvong, Kulika, Cate, Jamie H. D., Jin, Yong-Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430769/
https://www.ncbi.nlm.nih.gov/pubmed/30902987
http://dx.doi.org/10.1038/s41467-019-09288-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430769/
https://www.ncbi.nlm.nih.gov/pubmed/30902987
http://dx.doi.org/10.1038/s41467-019-09288-6

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