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Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells

The inability to inspect metabolic activities within subcellular compartments has been a major barrier to our understanding of eukaryotic cell metabolism. Here, we describe a spatial-fluxomics approach for inferring metabolic fluxes in mitochondria and cytosol under physiological conditions, combini...

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Detalles Bibliográficos
Autores principales: Lee, Won Dong, Mukha, Dzmitry, Aizenshtein, Elina, Shlomi, Tomer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430770/
https://www.ncbi.nlm.nih.gov/pubmed/30903027
http://dx.doi.org/10.1038/s41467-019-09352-1