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Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response
Growing evidence indicates that metabolic signaling pathways are interconnected to DNA damage response (DDR). However, factors that link metabolism to DDR remain incompletely understood. SIRT1, an NAD(+)-dependent deacetylase that regulates metabolism and aging, has been shown to protect cells from...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430805/ https://www.ncbi.nlm.nih.gov/pubmed/30902968 http://dx.doi.org/10.1038/s12276-019-0232-4 |