Dysfunction of the ubiquitin ligase E3A Ube3A/E6-AP contributes to synaptic pathology in Alzheimer’s disease

Synaptic dysfunction and synapse loss are prominent features in Alzheimer’s disease. Members of the Rho-family of guanosine triphosphatases, specifically RhoA, and the synaptic protein Arc are implicated in these pathogenic processes. They share a common regulatory molecule, the E3 ligase Ube3A/E6-A...

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Detalles Bibliográficos
Autores principales: Olabarria, Markel, Pasini, Silvia, Corona, Carlo, Robador, Pablo, Song, Cheng, Patel, Hardik, Lefort, Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430817/
https://www.ncbi.nlm.nih.gov/pubmed/30937395
http://dx.doi.org/10.1038/s42003-019-0350-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430817/
https://www.ncbi.nlm.nih.gov/pubmed/30937395
http://dx.doi.org/10.1038/s42003-019-0350-5

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