SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells

Endogenous retroviruses (ERVs) can confer benefits to their host but present a threat to genome integrity if not regulated correctly. Here we identify the SWI/SNF-like remodeler SMARCAD1 as a key factor in the control of ERVs in embryonic stem cells. SMARCAD1 is enriched at ERV subfamilies class I a...

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Detalles Bibliográficos
Autores principales: Sachs, Parysatis, Ding, Dong, Bergmaier, Philipp, Lamp, Boris, Schlagheck, Christina, Finkernagel, Florian, Nist, Andrea, Stiewe, Thorsten, Mermoud, Jacqueline E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430823/
https://www.ncbi.nlm.nih.gov/pubmed/30902974
http://dx.doi.org/10.1038/s41467-019-09078-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430823/
https://www.ncbi.nlm.nih.gov/pubmed/30902974
http://dx.doi.org/10.1038/s41467-019-09078-0

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