Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5

During infection, transcription factor interferon regulatory factor 5 (IRF5) is essential for the control of host defense. Here we show that the microtubule-associated guanine nucleotide exchange factor (GEF)-H1, is required for the phosphorylation of IRF5 by microbial muramyl-dipeptides (MDP), the...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Yun, Zagani, Rachid, Park, Sung-Moo, Yoshida, Naohiro, Shah, Pankaj, Reinecker, Hans-Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430831/
https://www.ncbi.nlm.nih.gov/pubmed/30902986
http://dx.doi.org/10.1038/s41467-019-09283-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430831/
https://www.ncbi.nlm.nih.gov/pubmed/30902986
http://dx.doi.org/10.1038/s41467-019-09283-x

Ejemplares similares