DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway

BACKGROUND: Macroautophagy (hereafter autophagy) is a tightly regulated process that delivers cellular components to lysosomes for degradation. Damage-regulated autophagy modulator 1 (DRAM1) induces autophagy and is necessary for p53-mediated apoptosis. However, the signalling pathways regulated by...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Ting, Zhu, Zhou, Wu, Junchao, She, Hua, Han, Rong, Xu, Haidong, Qin, Zheng-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431019/
https://www.ncbi.nlm.nih.gov/pubmed/30902093
http://dx.doi.org/10.1186/s12964-019-0341-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431019/
https://www.ncbi.nlm.nih.gov/pubmed/30902093
http://dx.doi.org/10.1186/s12964-019-0341-7

Ejemplares similares