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DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway

BACKGROUND: Macroautophagy (hereafter autophagy) is a tightly regulated process that delivers cellular components to lysosomes for degradation. Damage-regulated autophagy modulator 1 (DRAM1) induces autophagy and is necessary for p53-mediated apoptosis. However, the signalling pathways regulated by...

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Detalles Bibliográficos
Autores principales:	Lu, Ting, Zhu, Zhou, Wu, Junchao, She, Hua, Han, Rong, Xu, Haidong, Qin, Zheng-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431019/ https://www.ncbi.nlm.nih.gov/pubmed/30902093 http://dx.doi.org/10.1186/s12964-019-0341-7

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