HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2

The smallest histone deacetylase (HDAC) and the only class IV HDAC member, HDAC11, is reported to regulate immune activation and tumorigenesis, yet its biochemical function is largely unknown. Here we identify HDAC11 as an efficient lysine defatty-acylase that is >10,000-fold more efficient than...

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Detalles Bibliográficos
Autores principales: Cao, Ji, Sun, Lei, Aramsangtienchai, Pornpun, Spiegelman, Nicole A., Zhang, Xiaoyu, Huang, Weishan, Seto, Edward, Lin, Hening
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431144/
https://www.ncbi.nlm.nih.gov/pubmed/30819897
http://dx.doi.org/10.1073/pnas.1815365116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431144/
https://www.ncbi.nlm.nih.gov/pubmed/30819897
http://dx.doi.org/10.1073/pnas.1815365116

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