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Spastin is a dual-function enzyme that severs microtubules and promotes their regrowth to increase the number and mass of microtubules
The remodeling of the microtubule cytoskeleton underlies dynamic cellular processes, such as mitosis, ciliogenesis, and neuronal morphogenesis. An important class of microtubule remodelers comprises the severases—spastin, katanin, and fidgetin—which cut microtubules into shorter fragments. While sev...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431158/ https://www.ncbi.nlm.nih.gov/pubmed/30837315 http://dx.doi.org/10.1073/pnas.1818824116 |