Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration

Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene represent a cause of late-onset, autosomal dominant familial Parkinson’s disease (PD). A single missense mutation, D620N, is considered pathogenic based upon its segregation with disease in multiple families with PD. At present, the...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Kordich, Jennifer K., Williams, Erin T., Levine, Nathan, Cole-Strauss, Allyson, Marshall, Lee, Labrie, Viviane, Ma, Jiyan, Lipton, Jack W., Moore, Darren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431187/
https://www.ncbi.nlm.nih.gov/pubmed/30842285
http://dx.doi.org/10.1073/pnas.1814909116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431187/
https://www.ncbi.nlm.nih.gov/pubmed/30842285
http://dx.doi.org/10.1073/pnas.1814909116

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