FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX

OBJECTIVE: The generation of hyperglycemia-induced reactive oxygen species (ROS) is a key event in diabetic nephropathy (DN) development. Since forkhead box class O1 (FOXO1) is associated with oxidative stress and shows a positive effect on DN, its role on renal function and the underlying mechanism...

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Detalles Bibliográficos
Autores principales: Ji, Linlin, Wang, Qingzhu, Huang, Fengjuan, An, Tingting, Guo, Feng, Zhao, Yanyan, Liu, Yang, He, Yanyan, Song, Yi, Qin, Guijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431359/
https://www.ncbi.nlm.nih.gov/pubmed/30962862
http://dx.doi.org/10.1155/2019/3286928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431359/
https://www.ncbi.nlm.nih.gov/pubmed/30962862
http://dx.doi.org/10.1155/2019/3286928

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