Population Pharmacokinetics of Clozapine and Norclozapine and Switchability Assessment between Brands in Uruguayan Patients with Schizophrenia

Clozapine (CZP) is an atypical antipsychotic agent commonly used in the treatment of schizophrenia. It is metabolized primarily by CYP1A2 enzyme, yielding a pharmacologically active metabolite, norclozapine (NCZP). Significant intra- and interindividual pharmacokinetic (PK) variability for CZP and N...

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Detalles Bibliográficos
Autores principales: Olmos, Ismael, Ibarra, Manuel, Vázquez, Marta, Maldonado, Cecilia, Fagiolino, Pietro, Giachetto, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431368/
https://www.ncbi.nlm.nih.gov/pubmed/30956977
http://dx.doi.org/10.1155/2019/3163502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431368/
https://www.ncbi.nlm.nih.gov/pubmed/30956977
http://dx.doi.org/10.1155/2019/3163502

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