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Variability in the Drug Response of M(4) Muscarinic Receptor Knockout Mice During Day and Night Time
Mice are nocturnal animals. Surprisingly, the majority of physiological/pharmacological studies are performed in the morning, i.e., in the non-active phase of their diurnal cycle. We have shown recently that female (not male) mice lacking the M(4) muscarinic receptors (MR, M(4)KO) did not differ sub...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431655/ https://www.ncbi.nlm.nih.gov/pubmed/30936831 http://dx.doi.org/10.3389/fphar.2019.00237 |