Bruton's tyrosine kinase (Btk) inhibitor tirabrutinib suppresses osteoclastic bone resorption

Osteoclasts are responsible for bone erosion in osteoporosis and rheumatoid arthritis (RA). Both Btk and Tec kinases have essential functions in osteoclast differentiation. Tirabrutinib is a highly potent and dual oral Btk/Tec inhibitor with an IC(50) in the nmol/L range and significantly inhibits t...

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Detalles Bibliográficos
Autores principales: Ariza, Yuko, Murata, Masayuki, Ueda, Yoshiko, Yoshizawa, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431727/
https://www.ncbi.nlm.nih.gov/pubmed/30956999
http://dx.doi.org/10.1016/j.bonr.2019.100201