Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice

A series of amphiphilic peptides modified PMO (Pt-PMO) were prepared, and their antisense effect and toxicity were evaluated both in vitro and in mdx mice. The results showed that the exon-skipping performance of Pt-PMO are relative to the structure of the conjugated peptide: the Pt3/Pt4 composed of...

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Detalles Bibliográficos
Autores principales: Wang, Mingxing, Wu, Bo, Lu, Peijuan, Shah, Sapana N., Tucker, Jason D., Bollinger, Lauren E., Lu, Qilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432210/
https://www.ncbi.nlm.nih.gov/pubmed/30970855
http://dx.doi.org/10.3390/polym9050177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432210/
https://www.ncbi.nlm.nih.gov/pubmed/30970855
http://dx.doi.org/10.3390/polym9050177

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