Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity

To determine the target of the recently identified lead compound NSC130362 that is responsible for its selective anti-cancer efficacy and safety in normal cells, structure-activity relationship (SAR) studies were conducted. First, NSC13062 was validated as a starting compound for the described SAR s...

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Detalles Bibliográficos
Autores principales: Rozanov, Dmitri, Cheltsov, Anton, Nilsen, Aaron, Boniface, Christopher, Forquer, Isaac, Korkola, James, Gray, Joe, Tyner, Jeffrey, Tognon, Cristina E., Mills, Gordon B., Spellman, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433232/
https://www.ncbi.nlm.nih.gov/pubmed/30908483
http://dx.doi.org/10.1371/journal.pone.0205623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433232/
https://www.ncbi.nlm.nih.gov/pubmed/30908483
http://dx.doi.org/10.1371/journal.pone.0205623

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