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The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas
BACKGROUND: NRF2 is a major transcription factor regulating the expression of antioxidative/detoxifying enzymes, involved in oncogenic processes and drug resistance. We aimed to identify molecular alterations associated with NRF2 activation in endometrial carcinoma (EC). METHODS: Ninety patients tre...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433262/ https://www.ncbi.nlm.nih.gov/pubmed/30908539 http://dx.doi.org/10.1371/journal.pone.0214416 |