The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas

BACKGROUND: NRF2 is a major transcription factor regulating the expression of antioxidative/detoxifying enzymes, involved in oncogenic processes and drug resistance. We aimed to identify molecular alterations associated with NRF2 activation in endometrial carcinoma (EC). METHODS: Ninety patients tre...

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Detalles Bibliográficos
Autores principales: Beinse, Guillaume, Just, Pierre-Alexandre, Rance, Bastien, Izac, Brigitte, Letourneur, Franck, Saidu, Nathaniel Edward Bennett, Chouzenoux, Sandrine, Nicco, Carole, Goldwasser, François, Pasmant, Eric, Batteux, Frederic, Borghese, Bruno, Alexandre, Jérôme, Leroy, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433262/
https://www.ncbi.nlm.nih.gov/pubmed/30908539
http://dx.doi.org/10.1371/journal.pone.0214416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433262/
https://www.ncbi.nlm.nih.gov/pubmed/30908539
http://dx.doi.org/10.1371/journal.pone.0214416

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