Cargando…

The NRF2 transcriptional target NQO1 has low mRNA levels in TP53-mutated endometrial carcinomas

BACKGROUND: NRF2 is a major transcription factor regulating the expression of antioxidative/detoxifying enzymes, involved in oncogenic processes and drug resistance. We aimed to identify molecular alterations associated with NRF2 activation in endometrial carcinoma (EC). METHODS: Ninety patients tre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beinse, Guillaume, Just, Pierre-Alexandre, Rance, Bastien, Izac, Brigitte, Letourneur, Franck, Saidu, Nathaniel Edward Bennett, Chouzenoux, Sandrine, Nicco, Carole, Goldwasser, François, Pasmant, Eric, Batteux, Frederic, Borghese, Bruno, Alexandre, Jérôme, Leroy, Karen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433262/ https://www.ncbi.nlm.nih.gov/pubmed/30908539 http://dx.doi.org/10.1371/journal.pone.0214416

Ejemplares similares

Dimethyl fumarate is highly cytotoxic in KRAS mutated cancer cells but spares non-tumorigenic cells
por: Bennett Saidu, Nathaniel Edward, et al.
Publicado: (2018)

The Nrf2-Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma
por: Kavian, Niloufar, et al.
Publicado: (2018)

Corrigendum: The Nrf2-Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma
por: Kavian, Niloufar, et al.
Publicado: (2021)

LPS(low)-Macrophages Alleviate the Outcome of Graft-Versus-Host Disease Without Aggravating Lymphoma Growth in Mice
por: Jeljeli, Mohamed, et al.
Publicado: (2021)

Unbiased In Silico Analysis of Gene Expression Pinpoints Circulating miRNAs Targeting KIAA1324, a New Gene Drastically Downregulated in Ovarian Endometriosis
por: Abo, Carole, et al.
Publicado: (2022)

Preventive action of benztropine on platinum-induced peripheral neuropathies and tumor growth
por: Cerles, Olivier, et al.
Publicado: (2019)

Oxaliplatin-induced neuropathy: the preventive effect of a new super-oxide dismutase modulator
por: Guillaumot, Marie-Anne, et al.
Publicado: (2019)

Trained immunity modulates inflammation-induced fibrosis
por: Jeljeli, Mohamed, et al.
Publicado: (2019)

ROS Modulator Molecules with Therapeutic Potential in Cancers Treatments
por: Nicco, Carole, et al.
Publicado: (2017)

A New Manganese Superoxide Dismutase Mimetic Improves Oxaliplatin-Induced Neuropathy and Global Tolerance in Mice
por: Prieux-Klotz, Caroline, et al.
Publicado: (2022)

Therapeutic Potential of Anti-Interferon α Vaccination on SjS-Related Features in the MRL/lpr Autoimmune Mouse Model
por: Killian, Martin, et al.
Publicado: (2021)

CO/HO-1 Induces NQO-1 Expression via Nrf2 Activation
por: Kim, Hyo Jeong, et al.
Publicado: (2011)

Soluble Ligands for the NKG2D Receptor Are Released during Endometriosis and Correlate with Disease Severity
por: González-Foruria, Iñaki, et al.
Publicado: (2015)

The Effects of Allicin, a Reactive Sulfur Species from Garlic, on a Selection of Mammalian Cell Lines
por: Gruhlke, Martin C. H., et al.
Publicado: (2016)

Ultrasound-induced Cavitation enhances the efficacy of Chemotherapy in a 3D Model of Pancreatic Ductal Adenocarcinoma with its microenvironment
por: Leenhardt, R., et al.
Publicado: (2019)

Optimal combination of arsenic trioxide and copper ions to prevent autoimmunity in a murine HOCl-induced model of systemic sclerosis
por: Chêne, Charlotte, et al.
Publicado: (2023)

NQO1 promotes an aggressive phenotype in hepatocellular carcinoma via amplifying ERK‐NRF2 signaling
por: Yang, Yun, et al.
Publicado: (2020)

Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson’s disease by promoting Nrf2/NQO-1 pathway
por: Huang, Lijuan, et al.
Publicado: (2022)

The Potential Key Role of the NRF2/NQO1 Pathway in the Health Effects of Arsenic Pollution on SCC
por: Yang, Qianlei, et al.
Publicado: (2022)

Second‐trimester amniotic fluid proteins changes in subsequent spontaneous preterm birth
por: Marcellin, Louis, et al.
Publicado: (2023)

Correlation of NQO1 and Nrf2 in Female Genital Tract Cancer and Their Precancerous Lesions (Cervix, Endometrium and Ovary)
por: Osman, Nisreen Abdel Tawab Abdel Gaber, et al.
Publicado: (2015)

Sinomenine alleviates dextran sulfate sodium-induced colitis via the Nrf2/NQO-1 signaling pathway
por: Zhou, Yan, et al.
Publicado: (2018)

Expression of the NRF2 Target Gene NQO1 Is Enhanced in Mononuclear Cells in Human Chronic Kidney Disease
por: Shen, Jianlin, et al.
Publicado: (2017)

Nutritional Stress in Head and Neck Cancer Originating Cell Lines: The Sensitivity of the NRF2-NQO1 Axis
por: Milković, Lidija, et al.
Publicado: (2019)

Spatial Analysis of NQO1 in Non-Small Cell Lung Cancer Shows Its Expression Is Independent of NRF1 and NRF2 in the Tumor Microenvironment
por: Kaghazchi, Boback, et al.
Publicado: (2022)

Redox modulation of NQO1
por: Siegel, David, et al.
Publicado: (2018)

Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin
por: Grange, Philippe A., et al.
Publicado: (2009)

Docosahexanoic acid signals through the Nrf2–Nqo1 pathway to maintain redox balance and promote neurite outgrowth
por: Drolet, Jennifer, et al.
Publicado: (2021)

Forced Hepatic Expression of NRF2 or NQO1 Impedes Hepatocyte Lipid Accumulation in a Lipodystrophy Mouse Model
por: Wakabayashi, Nobunao, et al.
Publicado: (2023)

A Fenton-like cation can improve arsenic trioxide treatment of sclerodermatous chronic Graft-versus-Host Disease in mice
por: Chêne, Charlotte, et al.
Publicado: (2022)

A polymorphism in NAD(P)H:quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity.
por: Ross, D., et al.
Publicado: (1996)

Implications of NQO1 in cancer therapy
por: Oh, Eun-Taex, et al.
Publicado: (2015)

The Role of NQO1 in Ovarian Cancer
por: Tossetta, Giovanni, et al.
Publicado: (2023)

Dual-negative expression of Nrf2 and NQO1 predicts superior outcomes in patients with non-small cell lung cancer
por: Tong, Ying-Hui, et al.
Publicado: (2017)

Ruscogenins Improve CD-Like Enteritis by Inhibiting Apoptosis of Intestinal Epithelial Cells and Activating Nrf2/NQO1 Pathway
por: Wen, Hexin, et al.
Publicado: (2022)

Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
por: Dos Santos, Matthieu, et al.
Publicado: (2020)

Activation of NQO1 in NQO1*2 polymorphic human leukemic HL-60 cells by diet-derived sulforaphane
por: Wu, Joseph M., et al.
Publicado: (2016)

Therapeutic Potential of a Senolytic Approach in a Murine Model of Chronic GVHD
por: Raman, Deepika, et al.
Publicado: (2023)

Neferine Exerts Ferroptosis-Inducing Effect and Antitumor Effect on Thyroid Cancer through Nrf2/HO-1/NQO1 Inhibition
por: Li, Shujing, et al.
Publicado: (2022)

NQO1 protects against clioquinol toxicity
por: Chhetri, Jamuna, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gbld8s8jitr848npk4m67g143n