Potential roles of inorganic phosphate on the progression of initially bound glucopyranose toward the nonenzymatic glycation of human hemoglobin: mechanistic diversity and impacts on site selectivity

Nonenzymatic glycation (NEG) begins with the non-covalent binding of a glucopyranose to a protein. The bound glucopyranose must then undergo structural modification to generate a bound electrophile that can reversibly form a Schiff base, which can then lead to Amadori intermediates, and ultimately t...

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Detalles Bibliográficos
Autores principales: Smith, Brandy A., Mottishaw, Christina R., Hendricks, Andria J., Mitchell, Jason, Becker, Stephanie, Ropski, Pamela S., Park, Bomina, Finkbeiner-Caufield, Marie, Garay-Nontol, Barbara, Holman, R.W., Rodnick, Kenneth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433390/
https://www.ncbi.nlm.nih.gov/pubmed/30918913
http://dx.doi.org/10.1080/23312025.2018.1425196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433390/
https://www.ncbi.nlm.nih.gov/pubmed/30918913
http://dx.doi.org/10.1080/23312025.2018.1425196

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