Histone deacetylase inhibitor LMK235 attenuates vascular constriction and aortic remodelling in hypertension

Here, we report that LMK235, a class I and histone deacetylase (HDAC6)‐preferential HDAC inhibitor, reduces hypertension via inhibition of vascular contraction and vessel hypertrophy. Angiotensin II‐infusion mice and spontaneously hypertensive rats (SHRs) were used to test the anti‐hypertensive effe...

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Detalles Bibliográficos
Autores principales: Choi, Sin Young, Kee, Hae Jin, Sun, Simei, Seok, Young Mi, Ryu, Yuhee, Kim, Gwi Ran, Kee, Seung‐Jung, Pflieger, Marc, Kurz, Thomas, Kassack, Matthias U., Jeong, Myung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433685/
https://www.ncbi.nlm.nih.gov/pubmed/30734467
http://dx.doi.org/10.1111/jcmm.14188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433685/
https://www.ncbi.nlm.nih.gov/pubmed/30734467
http://dx.doi.org/10.1111/jcmm.14188

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