Cargando…

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models

α-Synuclein (α-syn) is a presynaptic protein that regulates the release of neurotransmitters from synaptic vesicles in the brain. α-Syn aggregates, including Lewy bodies, are features of both sporadic and familial forms of Parkinson's disease (PD). These aggregates undergo several key stages of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Javed, Hayate, Nagoor Meeran, Mohamed Fizur, Azimullah, Sheikh, Adem, Abdu, Sadek, Bassem, Ojha, Shreesh Kumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433754/ https://www.ncbi.nlm.nih.gov/pubmed/30941047 http://dx.doi.org/10.3389/fphar.2018.01555

Ejemplares similares

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
por: Nagoor Meeran, Mohamed Fizur, et al.
Publicado: (2017)

Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
por: Javed, Hayate, et al.
Publicado: (2023)

Neuroprotective Effects of Thymol, a Dietary Monoterpene Against Dopaminergic Neurodegeneration in Rotenone-Induced Rat Model of Parkinson’s Disease
por: Javed, Hayate, et al.
Publicado: (2019)

α-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson’s Disease
por: Javed, Hayate, et al.
Publicado: (2020)

Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson’s Disease
por: Jayaraj, Richard L., et al.
Publicado: (2019)

Myrcene Salvages Rotenone-Induced Loss of Dopaminergic Neurons by Inhibiting Oxidative Stress, Inflammation, Apoptosis, and Autophagy
por: Azimullah, Sheikh, et al.
Publicado: (2023)

Carvacrol, a Plant Metabolite Targeting Viral Protease (M(pro)) and ACE2 in Host Cells Can Be a Possible Candidate for COVID-19
por: Javed, Hayate, et al.
Publicado: (2021)

Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats
por: Azimullah, Sheikh, et al.
Publicado: (2023)

Limonene, a Monoterpene, Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Modulating Neuroinflammation, Hippo Signaling and Apoptosis in Rats
por: Eddin, Lujain Bader, et al.
Publicado: (2023)

α-Bisabolol Attenuates NF-κB/MAPK Signaling Activation and ER-Stress-Mediated Apoptosis by Invoking Nrf2-Mediated Antioxidant Defense Systems against Doxorubicin-Induced Testicular Toxicity in Rats
por: Arunachalam, Seenipandi, et al.
Publicado: (2022)

Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways
por: Jayaraj, Richard L., et al.
Publicado: (2020)

Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise
por: Nagoor Meeran, Mohamed Fizur, et al.
Publicado: (2018)

Cannabinoid Type 2 (CB(2)) Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson's Disease
por: Javed, Hayate, et al.
Publicado: (2016)

Noscapine Prevents Rotenone-Induced Neurotoxicity: Involvement of Oxidative Stress, Neuroinflammation and Autophagy Pathways
por: Jayaraj, Richard L., et al.
Publicado: (2021)

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease
por: Ojha, Shreesh, et al.
Publicado: (2015)

α-Bisabolol, a Dietary Sesquiterpene, Attenuates Doxorubicin-Induced Acute Cardiotoxicity in Rats by Inhibiting Cellular Signaling Pathways, Nrf2/Keap-1/HO-1, Akt/mTOR/GSK-3β, NF-κB/p38/MAPK, and NLRP3 Inflammasomes Regulating Oxidative Stress and Inflammatory Cascades
por: Nagoor Meeran, Mohamed Fizur, et al.
Publicado: (2023)

Therapeutic Potential of Plants and Plant Derived Phytochemicals against Acetaminophen-Induced Liver Injury
por: Subramanya, Sandeep B., et al.
Publicado: (2018)

β-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19
por: Jha, Niraj Kumar, et al.
Publicado: (2021)

Nerolidol Attenuates Oxidative Stress, Inflammation, and Apoptosis by Modulating Nrf2/MAPK Signaling Pathways in Doxorubicin-Induced Acute Cardiotoxicity in Rats
por: Arunachalam, Seenipandi, et al.
Publicado: (2021)

α-Bisabolol Attenuates Doxorubicin Induced Renal Toxicity by Modulating NF-κB/MAPK Signaling and Caspase-Dependent Apoptosis in Rats
por: Arunachalam, Seenipandi, et al.
Publicado: (2022)

Thymoquinone Protects against Myocardial Ischemic Injury by Mitigating Oxidative Stress and Inflammation
por: Ojha, Shreesh, et al.
Publicado: (2015)

Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone
por: Javed, Hayate, et al.
Publicado: (2016)

The Effect of Hypertension on the Recovery of Renal Dysfunction following Reversal of Unilateral Ureteral Obstruction in the Rat
por: Hammad, Fayez T., et al.
Publicado: (2023)

Can Echinacea be a potential candidate to target immunity, inflammation, and infection - The trinity of coronavirus disease 2019
por: Nagoor Meeran, M.F., et al.
Publicado: (2021)

Withania coagulans Fruit Extract Reduces Oxidative Stress and Inflammation in Kidneys of Streptozotocin-Induced Diabetic Rats
por: Ojha, Shreesh, et al.
Publicado: (2014)

Serratiopeptidase, A Serine Protease Anti-Inflammatory, Fibrinolytic, and Mucolytic Drug, Can Be a Useful Adjuvant for Management in COVID-19
por: Sharma, Charu, et al.
Publicado: (2021)

Therapeutic Potential of β-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications
por: Hashiesh, Hebaallah Mamdouh, et al.
Publicado: (2020)

Nootkatone, a Dietary Fragrant Bioactive Compound, Attenuates Dyslipidemia and Intramyocardial Lipid Accumulation and Favorably Alters Lipid Metabolism in a Rat Model of Myocardial Injury: An In Vivo and In Vitro Study
por: Meeran, M.F. Nagoor, et al.
Publicado: (2020)

Can limonene be a possible candidate for evaluation as an agent or adjuvant against infection, immunity, and inflammation in COVID-19?
por: Nagoor Meeran, M.F., et al.
Publicado: (2020)

The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats
por: Alachkar, Alaa, et al.
Publicado: (2019)

Neuroprotective Effect of Curcumin on the Nigrostriatal Pathway in a 6-Hydroxydopmine-Induced Rat Model of Parkinson’s Disease is Mediated by α7-Nicotinic Receptors
por: El Nebrisi, Eslam, et al.
Publicado: (2020)

Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats
por: Alachkar, Alaa, et al.
Publicado: (2020)

Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson's disease
por: Jayaraj, Richard L., et al.
Publicado: (2022)

Models of α-synuclein aggregation in Parkinson’s disease
por: Giráldez-Pérez, Rosa María, et al.
Publicado: (2014)

The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism
por: Eissa, Nermin, et al.
Publicado: (2018)

The Dual-Active Histamine H(3) Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice
por: Eissa, Nermin, et al.
Publicado: (2020)

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease
por: Tatenhorst, Lars, et al.
Publicado: (2016)

Modeling Parkinson’s Disease With the Alpha-Synuclein Protein
por: Gómez-Benito, Mónica, et al.
Publicado: (2020)

Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System
por: Rathod, Sumit S., et al.
Publicado: (2023)

miRNA and antisense oligonucleotide-based α-synuclein targeting as disease-modifying therapeutics in Parkinson’s disease
por: Suvarna, Vasanti, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0983t083rvie59fb24t730ocu1