Cargando…

Impaired Redox Signaling in Huntington’s Disease: Therapeutic Implications

Huntington’s disease (HD) is a neurodegenerative disease triggered by expansion of polyglutamine repeats in the protein huntingtin. Mutant huntingtin (mHtt) aggregates and elicits toxicity by multiple mechanisms which range from dysregulated transcription to disturbances in several metabolic pathway...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paul, Bindu D., Snyder, Solomon H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433839/ https://www.ncbi.nlm.nih.gov/pubmed/30941013 http://dx.doi.org/10.3389/fnmol.2019.00068

Ejemplares similares

Mutant Huntingtin Derails Cysteine Metabolism in Huntington’s Disease at Both Transcriptional and Post-Translational Levels
por: Paul, Bindu D., et al.
Publicado: (2022)

Huntington’s Disease and Striatal Signaling
por: Roze, Emmanuel, et al.
Publicado: (2011)

Editorial: Molecular Mechanisms of Thiol-Based Redox Homeostasis and Signaling in the Brain
por: Paul, Bindu Diana, et al.
Publicado: (2021)

Cannabinoid signaling and risk in Huntington's disease
por: Humble, James, et al.
Publicado: (2022)

Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease
por: Wiprich, Melissa Talita, et al.
Publicado: (2021)

Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
por: Weyemi, Urbain, et al.
Publicado: (2018)

Signaling Overlap between the Golgi Stress Response and Cysteine Metabolism in Huntington’s Disease
por: Paul, Bindu D.
Publicado: (2021)

Therapeutic Applications of Cysteamine and Cystamine in Neurodegenerative and Neuropsychiatric Diseases
por: Paul, Bindu D., et al.
Publicado: (2019)

Striatal Chloride Dysregulation and Impaired GABAergic Signaling Due to Cation-Chloride Cotransporter Dysfunction in Huntington’s Disease
por: Serranilla, Melissa, et al.
Publicado: (2022)

Huntington’s Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support
por: Garcia, Veronica J., et al.
Publicado: (2019)

Impaired Levels of Gangliosides in the Corpus Callosum of Huntington Disease Animal Models
por: Di Pardo, Alba, et al.
Publicado: (2016)

Regenerative Approaches in Huntington’s Disease: From Mechanistic Insights to Therapeutic Protocols
por: Sassone, Jenny, et al.
Publicado: (2018)

Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome
por: Paul, Bindu D., et al.
Publicado: (2021)

Editorial: New insight into Huntington's disease: From neuropathology to possible therapeutic targets
por: Estrada-Sánchez, Ana María, et al.
Publicado: (2023)

Small molecules to perform big roles: The search for Parkinson's and Huntington's disease therapeutics
por: Pérez-Arancibia, Rodrigo, et al.
Publicado: (2023)

Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease
por: El Massioui, Nicole, et al.
Publicado: (2016)

Altered Intracortical T(1)-Weighted/T(2)-Weighted Ratio Signal in Huntington’s Disease
por: Rowley, Christopher D., et al.
Publicado: (2018)

MicroRNAs in Huntington’s Disease: Diagnostic Biomarkers or Therapeutic Agents?
por: Dong, Xiaoyu, et al.
Publicado: (2021)

Corrigendum: Striatal Chloride Dysregulation and Impaired GABAergic Signaling Due to Cation-Chloride Cotransporter Dysfunction in Huntington's Disease
por: Serranilla, Melissa, et al.
Publicado: (2022)

Corticostriatal Dysfunction in Huntington’s Disease: The Basics
por: Bunner, Kendra D., et al.
Publicado: (2016)

The Role of Microglia and Astrocytes in Huntington’s Disease
por: Palpagama, Thulani H., et al.
Publicado: (2019)

Contribution of Neuroepigenetics to Huntington’s Disease
por: Francelle, Laetitia, et al.
Publicado: (2017)

Acanthocytes Identified in Huntington’s Disease
por: Yu, Yueyi, et al.
Publicado: (2022)

Commentary: Acanthocytes identified in Huntington's disease
por: Peikert, Kevin, et al.
Publicado: (2022)

On the Right Track to Treat Movement Disorders: Promising Therapeutic Approaches for Parkinson’s and Huntington’s Disease
por: Troncoso-Escudero, Paulina, et al.
Publicado: (2020)

Impairment and Restoration of Homeostatic Plasticity in Cultured Cortical Neurons From a Mouse Model of Huntington Disease
por: Smith-Dijak, Amy I., et al.
Publicado: (2019)

Novel EAAT2 activators improve motor and cognitive impairment in a transgenic model of Huntington’s disease
por: Bhatnagar, Akanksha, et al.
Publicado: (2023)

Reactive Neuroblastosis in Huntington’s Disease: A Putative Therapeutic Target for Striatal Regeneration in the Adult Brain
por: Kandasamy, Mahesh, et al.
Publicado: (2018)

Mitochondrial and redox modifications in early stages of Huntington's disease
por: Lopes, Carla, et al.
Publicado: (2022)

Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington’s Disease
por: Nguyen, Khanh Q., et al.
Publicado: (2016)

Microglial Activation in the Pathogenesis of Huntington’s Disease
por: Yang, Hui-Ming, et al.
Publicado: (2017)

Cortical and Striatal Circuits in Huntington’s Disease
por: Blumenstock, Sonja, et al.
Publicado: (2020)

Altered Cholesterol Homeostasis in Huntington’s Disease
por: Kacher, Radhia, et al.
Publicado: (2022)

Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking
por: Wilson, Carlos, et al.
Publicado: (2015)

Inositol polyphosphate multikinase modulates redox signaling through nuclear factor erythroid 2-related factor 2 and glutathione metabolism
por: Tyagi, Richa, et al.
Publicado: (2023)

Dysregulated Neuronal Activity Patterns Implicate Corticostriatal Circuit Dysfunction in Multiple Rodent Models of Huntington's Disease
por: Miller, Benjamin R., et al.
Publicado: (2011)

Implications of Tau Dysregulation in Huntington’s Disease and Potential for New Therapeutics
por: Mees, Isaline, et al.
Publicado: (2023)

Impaired Performance of the Q175 Mouse Model of Huntington’s Disease in the Touch Screen Paired Associates Learning Task
por: Piiponniemi, Tuukka O., et al.
Publicado: (2018)

Redox signaling and metabolism in Alzheimer's disease
por: Holubiec, M. I., et al.
Publicado: (2022)

Role of cerebral cortex in the neuropathology of Huntington's disease
por: Estrada-Sánchez, Ana M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_1fc3kmes4bi5uisrpgu7f0lve5