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Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome Editing

Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of hematological and solid malignancies. However, despite the success of this field, there remain some major challenges, including accelerated T cell exhaustion, potential toxicities, and insertional oncogenesis. To ov...

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Detalles Bibliográficos
Autores principales: Liu, Jie, Zhou, Guangyu, Zhang, Li, Zhao, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433930/
https://www.ncbi.nlm.nih.gov/pubmed/30941126
http://dx.doi.org/10.3389/fimmu.2019.00456