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Building Potent Chimeric Antigen Receptor T Cells With CRISPR Genome Editing
Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of hematological and solid malignancies. However, despite the success of this field, there remain some major challenges, including accelerated T cell exhaustion, potential toxicities, and insertional oncogenesis. To ov...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433930/ https://www.ncbi.nlm.nih.gov/pubmed/30941126 http://dx.doi.org/10.3389/fimmu.2019.00456 |