Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity

Fludioxonil, a natural product of pyrrolnitrin, is a potent fungicide used on crops worldwide. Drug action requires the presence of a group III hybrid histidine kinase (HHK) and the high osmolarity glycerol (HOG) pathway. We have reported that the drug does not act directly on HHK, but triggers the...

Descripción completa

Detalles Bibliográficos
Autores principales: Brandhorst, T. Tristan, Kean, Iain R. L., Lawry, Stephanie M., Wiesner, Darin L., Klein, Bruce S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433957/
https://www.ncbi.nlm.nih.gov/pubmed/30911085
http://dx.doi.org/10.1038/s41598-019-41564-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433957/
https://www.ncbi.nlm.nih.gov/pubmed/30911085
http://dx.doi.org/10.1038/s41598-019-41564-9

Ejemplares similares