Position 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity

HheG from Ilumatobacter coccineus is a halohydrin dehalogenase with synthetically useful activity in the ring opening of cyclic epoxides with various small anionic nucleophiles. This enzyme provides access to chiral β-substituted alcohols that serve as building blocks in the pharmaceutical industry....

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Detalles Bibliográficos
Autores principales: Solarczek, Jennifer, Klünemann, Thomas, Brandt, Felix, Schrepfer, Patrick, Wolter, Mario, Jacob, Christoph R., Blankenfeldt, Wulf, Schallmey, Anett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434027/
https://www.ncbi.nlm.nih.gov/pubmed/30911023
http://dx.doi.org/10.1038/s41598-019-41498-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434027/
https://www.ncbi.nlm.nih.gov/pubmed/30911023
http://dx.doi.org/10.1038/s41598-019-41498-2

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