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Position 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity
HheG from Ilumatobacter coccineus is a halohydrin dehalogenase with synthetically useful activity in the ring opening of cyclic epoxides with various small anionic nucleophiles. This enzyme provides access to chiral β-substituted alcohols that serve as building blocks in the pharmaceutical industry....
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434027/ https://www.ncbi.nlm.nih.gov/pubmed/30911023 http://dx.doi.org/10.1038/s41598-019-41498-2 |