Time-dependent inhibition of PHD2

Prolyl hydroxylases (PHDs) down-regulate the level of hypoxia-inducible factors (HIFs) by hydroxylating key proline residues that trigger the degradation of the protein and affect the cell and its ability to respond to hypoxic stress. Several small molecule PHD inhibitors are now in various preclini...

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Detalles Bibliográficos
Autores principales: Tcholakov, Isabelle, Grimshaw, Charles E., Shi, Lihong, Kiryanov, Andre, Murphy, Sean T., Larson, Christopher J., Plonowski, Artur, Ermolieff, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434079/
https://www.ncbi.nlm.nih.gov/pubmed/28592559
http://dx.doi.org/10.1042/BSR20170275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434079/
https://www.ncbi.nlm.nih.gov/pubmed/28592559
http://dx.doi.org/10.1042/BSR20170275

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