Cargando…

Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare

BACKGROUND: Horehound (Marrubium vulgare) is a medicinal plant whose signature bioactive compounds, marrubiin and related furanoid diterpenoid lactones, have potential applications for the treatment of cardiovascular diseases and type II diabetes. Lack of scalable plant cultivation and the complex m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karunanithi, Prema S., Dhanota, Puja, Addison, J. Bennett, Tong, Shen, Fiehn, Oliver, Zerbe, Philipp
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434833/ https://www.ncbi.nlm.nih.gov/pubmed/30909879 http://dx.doi.org/10.1186/s12870-019-1702-5

Ejemplares similares

Supercritical CO(2) extraction of Marrubium vulgare: intensification of marrubiin
por: Gavarić, Aleksandra, et al.
Publicado: (2021)

Chromatographic Fingerprint Analysis of Marrubiin in Marrubium vulgare L. via HPTLC Technique
por: Yousefi, Keyvan, et al.
Publicado: (2016)

Intensification of marrubiin concentration by optimization of microwave-assisted (low CO(2) yielding) extraction process for Marrubium vulgare using central composite design and antioxidant evaluation
por: Mittal, Vineet, et al.
Publicado: (2017)

Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice
por: Nidhi,, et al.
Publicado: (2022)

Marrubiin
por: Popoola, Olugbenga K., et al.
Publicado: (2013)

Marrubium vulgare L.: A Phytochemical and Pharmacological Overview
por: Aćimović, Milica, et al.
Publicado: (2020)

Chemical Characterization of Marrubium vulgare Volatiles from Serbia
por: Aćimović, Milica, et al.
Publicado: (2021)

Evaluation of the Antioxidant Activity of Saponins Extracts in Marrubium vulgare L.
por: Amnay, Abdellatif, et al.
Publicado: (2022)

Taxonomic Distribution of Cytochrome P450 Monooxygenases (CYPs) among the Budding Yeasts (Sub-Phylum Saccharomycotina)
por: Linder, Tomas
Publicado: (2019)

Diversity and evolution of cytochrome P450 monooxygenases in Oomycetes
por: Sello, Mopeli Marshal, et al.
Publicado: (2015)

Versatile biocatalysis of fungal cytochrome P450 monooxygenases
por: Durairaj, Pradeepraj, et al.
Publicado: (2016)

Chemical Composition and In Vitro Antioxidant and Antimicrobial Activities of Marrubium vulgare L.
por: Mssillou, Ibrahim, et al.
Publicado: (2021)

Cytochrome P450 Monooxygenase CYP139 Family Involved in the Synthesis of Secondary Metabolites in 824 Mycobacterial Species
por: Syed, Puleng Rosinah, et al.
Publicado: (2019)

In Silico Structural Modeling and Analysis of Interactions of Tremellomycetes Cytochrome P450 Monooxygenases CYP51s with Substrates and Azoles
por: Akapo, Olufunmilayo Olukemi, et al.
Publicado: (2021)

Insights into the Cytochrome P450 Monooxygenase Superfamily in Osmanthus fragrans and the Role of OfCYP142 in Linalool Synthesis
por: Liu, Jiawei, et al.
Publicado: (2022)

Cytochrome P-450 isozymes and monooxygenase activity in aquatic animals.
por: Stegeman, J J, et al.
Publicado: (1987)

Prediction and analysis of the modular structure of cytochrome P450 monooxygenases
por: Sirim, Demet, et al.
Publicado: (2010)

Specificity and mechanism of carbohydrate demethylation by cytochrome P450 monooxygenases
por: Robb, Craig S., et al.
Publicado: (2018)

Evaluation of Antioxidant Activity of Alkaloid Extracts Obtained From Marrubium vulgare L.
por: Ouriagli, Taha, et al.
Publicado: (2022)

Characterization of cytochrome P450 monooxygenase CYP154H1 from the thermophilic soil bacterium Thermobifida fusca
por: Schallmey, Anett, et al.
Publicado: (2010)

CYP709B3, a cytochrome P450 monooxygenase gene involved in salt tolerance in Arabidopsis thaliana
por: Mao, Guohong, et al.
Publicado: (2013)

RNA interference in cytochrome P450 monooxygenase (CYP) gene results in reduced insecticide resistance in Megalurothrips usitatus Bagnall
por: Chen, Weiyi, et al.
Publicado: (2023)

Correction: Prediction and analysis of the modular structure of cytochrome P450 monooxygenases
por: Sirim, Demet, et al.
Publicado: (2012)

Distribution and Diversity of Cytochrome P450 Monooxygenases in the Fungal Class Tremellomycetes
por: Akapo, Olufunmilayo Olukemi, et al.
Publicado: (2019)

Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer
por: Luo, Ying, et al.
Publicado: (2020)

Cytochrome P450 monooxygenase genes in the wild silkworm, Bombyx mandarina
por: Wan, Linrong, et al.
Publicado: (2021)

Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants
por: Malhotra, Karan, et al.
Publicado: (2022)

Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties
por: Amri, Bédis, et al.
Publicado: (2017)

Evaluation of Marrubium vulgare Growing Wild in Tunisia for Its Potential as a Dietary Supplement
por: Rezgui, Marwa, et al.
Publicado: (2021)

The Application of Ultrasonic Waves and Microwaves to Improve Antihyperglycaemic and Antimicrobial Activities of Marrubium vulgare Extracts
por: Gavarić, Aleksandra, et al.
Publicado: (2022)

A cytochrome P450 CYP87A4 imparts sterol side-chain cleavage in digoxin biosynthesis
por: Carroll, Emily, et al.
Publicado: (2023)

Transcriptional regulation of the grape cytochrome P450 monooxygenase gene CYP736B expression in response to Xylella fastidiosa infection
por: Cheng, Davis W, et al.
Publicado: (2010)

The cytochrome P450 (CYP) superfamily in cnidarians
por: Pankov, Kirill V., et al.
Publicado: (2021)

ANTIHEPATOTOXIC EFFECT OF MARRUBIUM VULGARE AND WITHANIA SOMNIFERA EXTRACTS ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS
por: Elberry, Ahmed A., et al.
Publicado: (2010)

Cytochrome P450 CYP71BE5 in grapevine (Vitis vinifera) catalyzes the formation of the spicy aroma compound (−)-rotundone
por: Takase, Hideki, et al.
Publicado: (2016)

Evolution of substrate recognition sites (SRSs) in cytochromes P450 from Apiaceae exemplified by the CYP71AJ subfamily
por: Dueholm, Bjørn, et al.
Publicado: (2015)

Identification and characterization of CYP71 subclade cytochrome P450 enzymes involved in the biosynthesis of bitterness compounds in Cichorium intybus
por: De Bruyn, Charlotte, et al.
Publicado: (2023)

Molecular evolutionary dynamics of cytochrome P450 monooxygenases across kingdoms: Special focus on mycobacterial P450s
por: Parvez, Mohammad, et al.
Publicado: (2016)

Characterization of the cytochrome P450 monooxygenase genes (P450ome) from the carotenogenic yeast Xanthophyllomyces dendrorhous
por: Córdova, Pamela, et al.
Publicado: (2017)

Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11
por: Vottero, Eduardo, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_j1ocpdlop9u0pf1kcaaijooe1q