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CDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the G2/M phase and inhibiting transcriptional activity in cervical cancer

BACKGROUND: The disordered cell cycle and dysregulated expression of numerous oncogenes involved in tumor-relevant processes are highly related to the tumorigenesis of cervical cancer. Cyclin-dependent kinase 7 (CDK7) constitutes the indispensable catalytic subunit of CDK-activating kinase (CAK), wh...

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Detalles Bibliográficos
Autores principales:	Zhong, Shanshan, Zhang, Yi, Yin, Xia, Di, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434917/ https://www.ncbi.nlm.nih.gov/pubmed/30962695 http://dx.doi.org/10.2147/OTT.S195655

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