Functional significance of HCM mutants of tropomyosin, V95A and D175N, studied with in vitro motility assays

The majority of hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere proteins. We examined tropomyosin (Tpm)’s HCM mutants in humans, V95A and D175N, with in vitro motility assay using optical tweezers to evaluate the effects of the Tpm mutations on the actomyosin interaction at the...

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Detalles Bibliográficos
Autores principales: Ishii, Shuya, Suzuki, Madoka, Ishiwata, Shin’ichi, Kawai, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society of Japan (BSJ) 2019
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435021/
https://www.ncbi.nlm.nih.gov/pubmed/30923661
http://dx.doi.org/10.2142/biophysico.16.0_28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435021/
https://www.ncbi.nlm.nih.gov/pubmed/30923661
http://dx.doi.org/10.2142/biophysico.16.0_28

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