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Nutritional stress targets LeishIF4E-3 to storage granules that contain RNA and ribosome components in Leishmania
Leishmania parasites lack pathways for de novo purine biosynthesis. The depletion of purines induces differentiation into virulent metacyclic forms. In vitro, the parasites can survive prolonged periods of purine withdrawal changing their morphology to long and slender cells with an extended flagell...
Autores principales: | Shrivastava, Rohit, Drory-Retwitzer, Matan, Shapira, Michal |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435199/ https://www.ncbi.nlm.nih.gov/pubmed/30870425 http://dx.doi.org/10.1371/journal.pntd.0007237 |
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