Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming

Forced transcription factor expression can transdifferentiate somatic cells into other specialised cell types or reprogram them into induced pluripotent stem cells (iPSCs) with variable efficiency. To better understand the heterogeneity of these processes, we used single-cell RNA sequencing to follo...

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Detalles Bibliográficos
Autores principales: Francesconi, Mirko, Di Stefano, Bruno, Berenguer, Clara, de Andrés-Aguayo, Luisa, Plana-Carmona, Marcos, Mendez-Lago, Maria, Guillaumet-Adkins, Amy, Rodriguez-Esteban, Gustavo, Gut, Marta, Gut, Ivo G, Heyn, Holger, Lehner, Ben, Graf, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435319/
https://www.ncbi.nlm.nih.gov/pubmed/30860479
http://dx.doi.org/10.7554/eLife.41627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435319/
https://www.ncbi.nlm.nih.gov/pubmed/30860479
http://dx.doi.org/10.7554/eLife.41627

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