Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells

Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent functional screening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite instability-high (MSI-H) cancer cells. MSI, caused...

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Detalles Bibliográficos
Autores principales: Lieb, Simone, Blaha-Ostermann, Silvia, Kamper, Elisabeth, Rippka, Janine, Schwarz, Cornelia, Ehrenhöfer-Wölfer, Katharina, Schlattl, Andreas, Wernitznig, Andreas, Lipp, Jesse J, Nagasaka, Kota, van der Lelij, Petra, Bader, Gerd, Koi, Minoru, Goel, Ajay, Neumüller, Ralph A, Peters, Jan-Michael, Kraut, Norbert, Pearson, Mark A, Petronczki, Mark, Wöhrle, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435321/
https://www.ncbi.nlm.nih.gov/pubmed/30910006
http://dx.doi.org/10.7554/eLife.43333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435321/
https://www.ncbi.nlm.nih.gov/pubmed/30910006
http://dx.doi.org/10.7554/eLife.43333

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