Leveraging Spatial Variation in Tumor Purity for Improved Somatic Variant Calling of Archival Tumor Only Samples

Archival tumor samples represent a rich resource of annotated specimens for translational genomics research. However, standard variant calling approaches require a matched normal sample from the same individual, which is often not available in the retrospective setting, making it difficult to distin...

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Detalles Bibliográficos
Autores principales: Halperin, Rebecca F., Liang, Winnie S., Kulkarni, Sidharth, Tassone, Erica E., Adkins, Jonathan, Enriquez, Daniel, Tran, Nhan L., Hank, Nicole C., Newell, James, Kodira, Chinnappa, Korn, Ronald, Berens, Michael E., Kim, Seungchan, Byron, Sara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435595/
https://www.ncbi.nlm.nih.gov/pubmed/30949446
http://dx.doi.org/10.3389/fonc.2019.00119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435595/
https://www.ncbi.nlm.nih.gov/pubmed/30949446
http://dx.doi.org/10.3389/fonc.2019.00119

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