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Pleiotropic Effects of IL-33 on CD4(+) T Cell Differentiation and Effector Functions
IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a promoter of type 2 immune responses. However, recent evidence reveals a more complex picture. This cytokine is released locally as an alarmin upon cellular damage where innate cell types respond to IL-33 by modula...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435597/ https://www.ncbi.nlm.nih.gov/pubmed/30949175 http://dx.doi.org/10.3389/fimmu.2019.00522 |
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author | Alvarez, Fernando Fritz, Jörg H. Piccirillo, Ciriaco A. |
author_facet | Alvarez, Fernando Fritz, Jörg H. Piccirillo, Ciriaco A. |
author_sort | Alvarez, Fernando |
collection | PubMed |
description | IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a promoter of type 2 immune responses. However, recent evidence reveals a more complex picture. This cytokine is released locally as an alarmin upon cellular damage where innate cell types respond to IL-33 by modulating their differentiation and influencing the polarizing signals they provide to T cells at the time of antigen presentation. Moreover, the prominent expression of the IL-33 receptor, ST2, on GATA3(+) T helper 2 cells (T(H)2) demonstrated that IL-33 could have a direct impact on T cells. Recent observations reveal that T-bet(+) T(H)1 cells and Foxp3(+) regulatory T (T(REG)) cells can also express the ST2 receptor, either transiently or permanently. As such, IL-33 can have a direct effect on the dynamics of T cell populations. As IL-33 release was shown to play both an inflammatory and a suppressive role, understanding the complex effect of this cytokine on T cell homeostasis is paramount. In this review, we will focus on the factors that modulate ST2 expression on T cells, the effect of IL-33 on helper T cell responses and the role of IL-33 on T(REG) cell function. |
format | Online Article Text |
id | pubmed-6435597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64355972019-04-04 Pleiotropic Effects of IL-33 on CD4(+) T Cell Differentiation and Effector Functions Alvarez, Fernando Fritz, Jörg H. Piccirillo, Ciriaco A. Front Immunol Immunology IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a promoter of type 2 immune responses. However, recent evidence reveals a more complex picture. This cytokine is released locally as an alarmin upon cellular damage where innate cell types respond to IL-33 by modulating their differentiation and influencing the polarizing signals they provide to T cells at the time of antigen presentation. Moreover, the prominent expression of the IL-33 receptor, ST2, on GATA3(+) T helper 2 cells (T(H)2) demonstrated that IL-33 could have a direct impact on T cells. Recent observations reveal that T-bet(+) T(H)1 cells and Foxp3(+) regulatory T (T(REG)) cells can also express the ST2 receptor, either transiently or permanently. As such, IL-33 can have a direct effect on the dynamics of T cell populations. As IL-33 release was shown to play both an inflammatory and a suppressive role, understanding the complex effect of this cytokine on T cell homeostasis is paramount. In this review, we will focus on the factors that modulate ST2 expression on T cells, the effect of IL-33 on helper T cell responses and the role of IL-33 on T(REG) cell function. Frontiers Media S.A. 2019-03-20 /pmc/articles/PMC6435597/ /pubmed/30949175 http://dx.doi.org/10.3389/fimmu.2019.00522 Text en Copyright © 2019 Alvarez, Fritz and Piccirillo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Alvarez, Fernando Fritz, Jörg H. Piccirillo, Ciriaco A. Pleiotropic Effects of IL-33 on CD4(+) T Cell Differentiation and Effector Functions |
title | Pleiotropic Effects of IL-33 on CD4(+) T Cell Differentiation and Effector Functions |
title_full | Pleiotropic Effects of IL-33 on CD4(+) T Cell Differentiation and Effector Functions |
title_fullStr | Pleiotropic Effects of IL-33 on CD4(+) T Cell Differentiation and Effector Functions |
title_full_unstemmed | Pleiotropic Effects of IL-33 on CD4(+) T Cell Differentiation and Effector Functions |
title_short | Pleiotropic Effects of IL-33 on CD4(+) T Cell Differentiation and Effector Functions |
title_sort | pleiotropic effects of il-33 on cd4(+) t cell differentiation and effector functions |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435597/ https://www.ncbi.nlm.nih.gov/pubmed/30949175 http://dx.doi.org/10.3389/fimmu.2019.00522 |
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