PMCA-replicated PrP(D) in urine of vCJD patients maintains infectivity and strain characteristics of brain PrP(D): Transmission study

The presence of abnormal, disease-related prion protein (PrP(D)) has recently been demonstrated by protein misfolding cyclic amplification (PMCA) in urine of patients affected with variant Creutzfeldt-Jakob disease (vCJD), a prion disease typically acquired from consumption of prion contaminated bov...

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Detalles Bibliográficos
Autores principales: Cali, Ignazio, Lavrich, Jody, Moda, Fabio, Kofskey, Diane, Nemani, Satish Kumar, Appleby, Brian, Tagliavini, Fabrizio, Soto, Claudio, Gambetti, Pierluigi, Notari, Silvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435672/
https://www.ncbi.nlm.nih.gov/pubmed/30914754
http://dx.doi.org/10.1038/s41598-019-41694-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435672/
https://www.ncbi.nlm.nih.gov/pubmed/30914754
http://dx.doi.org/10.1038/s41598-019-41694-0

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