Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability

HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs joined by less understood linker regions. Our recent competitive deep mutational scanning study confirmed m...

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Detalles Bibliográficos
Autores principales: Jayaraman, Bhargavi, Fernandes, Jason D., Yang, Shumin, Smith, Cynthia, Frankel, Alan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435700/
https://www.ncbi.nlm.nih.gov/pubmed/30914719
http://dx.doi.org/10.1038/s41598-019-41582-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435700/
https://www.ncbi.nlm.nih.gov/pubmed/30914719
http://dx.doi.org/10.1038/s41598-019-41582-7

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