Cargando…

Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability

HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs joined by less understood linker regions. Our recent competitive deep mutational scanning study confirmed m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jayaraman, Bhargavi, Fernandes, Jason D., Yang, Shumin, Smith, Cynthia, Frankel, Alan D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435700/ https://www.ncbi.nlm.nih.gov/pubmed/30914719 http://dx.doi.org/10.1038/s41598-019-41582-7

Ejemplares similares

The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex
por: Fernandes, Jason, et al.
Publicado: (2012)

RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex
por: Jayaraman, Bhargavi, et al.
Publicado: (2014)

Functional and structural segregation of overlapping helices in HIV-1
por: Safari, Maliheh, et al.
Publicado: (2022)

Structural basis for cooperative RNA binding and export complex assembly by HIV Rev
por: Daugherty, Matthew D., et al.
Publicado: (2010)

Mutability of prions
por: Li, Jiali, et al.
Publicado: (2011)

Un planeta mutable /
por: Medina Martínez, Francisco
Publicado: (1995)

RNAs: dynamic and mutable
por: Zavolan, Mihaela, et al.
Publicado: (2017)

The Mutability of Yeast Prions
por: King, Chih-Yen
Publicado: (2022)

In vitro replication highlights the mutability of prions
por: Vanni, Ilaria, et al.
Publicado: (2014)

Semantic Annotation of Mutable Data
por: Morris, Robert A., et al.
Publicado: (2013)

Maximally mutable Laurent polynomials
por: Coates, Tom, et al.
Publicado: (2021)

HIV Rev Assembly on the Rev Response Element (RRE): A Structural Perspective
por: Rausch, Jason W., et al.
Publicado: (2015)

Mechanically mutable polymer enabled by light
por: Cai, Feng, et al.
Publicado: (2022)

HIV Rev-isited
por: Truman, Catherine Toni-Sue, et al.
Publicado: (2020)

Using Mutability Landscapes To Guide Enzyme Thermostabilization
por: Guo, Chao, et al.
Publicado: (2020)

Mutability of demographic noise in microbial range expansions
por: Yu, QinQin, et al.
Publicado: (2021)

Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome
por: Gorlov, Ivan P, et al.
Publicado: (2008)

Editorial: Highly Mutable Animal RNA Viruses: Adaptation and Evolution
por: Nomaguchi, Masako, et al.
Publicado: (2017)

Matrin 3 and HIV Rev Regulation of mRNA
por: Dayton, Andrew I
Publicado: (2011)

Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection
por: Sheng, Zizhang, et al.
Publicado: (2016)

Regulation of Rev1 by the Fanconi Anemia Core Complex
por: Kim, Hyungjin, et al.
Publicado: (2012)

Multiple genetic switches spontaneously modulating bacterial mutability
por: Chen, Fang, et al.
Publicado: (2010)

Mutability and mutational spectrum of chromosome transmission fidelity genes
por: Stirling, Peter C., et al.
Publicado: (2011)

An Investigation into the Mutability of Information in Production Grid Information Systems
por: Field, L, et al.
Publicado: (2009)

How homologous recombination generates a mutable genome
por: Hurles, Matthew
Publicado: (2005)

Plasmid Copy Number Underlies Adaptive Mutability in Bacteria
por: Sano, Emiko, et al.
Publicado: (2014)

The Generation and Exploitation of Protein Mutability Landscapes for Enzyme Engineering
por: van der Meer, Jan‐Ytzen, et al.
Publicado: (2016)

Drug-Targeted Genomes: Mutability of Ion Channels and GPCRs
por: Raines, Regan, et al.
Publicado: (2022)

Rev-Rev Response Element Activity Selection Bias at the HIV Transmission Bottleneck
por: Jackson, Patrick E. H., et al.
Publicado: (2023)

Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome
por: Li, Jian, et al.
Publicado: (2012)

Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import
por: Gu, Lili, et al.
Publicado: (2011)

Regulation of Circadian Behavior and Metabolism by Rev-erbα and Rev-erbβ
por: Cho, Han, et al.
Publicado: (2012)

A de novo peptide hexamer with a mutable channel
por: Zaccai, Nathan R., et al.
Publicado: (2011)

Increased Mutability of Staphylococci in Biofilms as a Consequence of Oxidative Stress
por: Ryder, Victoria J., et al.
Publicado: (2012)

Entropy and Mutability for the q-State Clock Model in Small Systems
por: Negrete, Oscar A., et al.
Publicado: (2018)

SARS-Cov-2 ORF3a: Mutability and function
por: Bianchi, Martina, et al.
Publicado: (2021)

Computer modeling reveals modalities to actuate mutable, active matter
por: Laskar, Abhrajit, et al.
Publicado: (2022)

Dynamics of HIV-1 Rev sub-nuclear trafficking reveal new insight into the role of RNA in the regulation of Rev nucleolar accumulation
por: Woods, Elena, et al.
Publicado: (2013)

Selection and Neutral Mutations Drive Pervasive Mutability Losses in Long-Lived Anti-HIV B-Cell Lineages
por: Vieira, Marcos C, et al.
Publicado: (2018)

Correction: Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_rf1u4mlvh62nqm0b2p7tliscu6