ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects

Mitochondrial fragmentation and bioenergetic failure manifest in Huntington’s disease (HD), a fatal neurodegenerative disease. The factors that couple mitochondrial fusion/fission with bioenergetics and their impacts on neurodegeneration however remain poorly understood. Our proteomic analysis ident...

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Detalles Bibliográficos
Autores principales: Zhao, Yuanyuan, Sun, Xiaoyan, Hu, Di, Prosdocimo, Domenick A., Hoppel, Charles, Jain, Mukesh K., Ramachandran, Rajesh, Qi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435701/
https://www.ncbi.nlm.nih.gov/pubmed/30914652
http://dx.doi.org/10.1038/s41467-019-09291-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435701/
https://www.ncbi.nlm.nih.gov/pubmed/30914652
http://dx.doi.org/10.1038/s41467-019-09291-x

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