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Membrane insertion and secretion of the Engrailed-2 (EN2) transcription factor by prostate cancer cells may induce antiviral activity in the stroma

Engrailed-2 (EN2) is a homeodomain-containing transcription factor that has roles in boundary formation and neural guidance in early development, but which is also expressed in a range of cancers. In addition to transcriptional regulation, it is secreted by cells and taken up by others through a mec...

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Detalles Bibliográficos
Autores principales: Punia, Natasha, Primon, Monika, Simpson, Guy R., Pandha, Hardev S., Morgan, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435720/
https://www.ncbi.nlm.nih.gov/pubmed/30914795
http://dx.doi.org/10.1038/s41598-019-41678-0