Thymic Epithelium Abnormalities in DiGeorge and Down Syndrome Patients Contribute to Dysregulation in T Cell Development

The thymus plays a fundamental role in establishing and maintaining central and peripheral tolerance and defects in thymic architecture or AIRE expression result in the development of autoreactive lymphocytes. Patients with partial DiGeorge Syndrome (pDGS) and Down Syndrome (DS) present alterations...

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Detalles Bibliográficos
Autores principales: Marcovecchio, Genni Enza, Bortolomai, Ileana, Ferrua, Francesca, Fontana, Elena, Imberti, Luisa, Conforti, Erika, Amodio, Donato, Bergante, Sonia, Macchiarulo, Giulia, D'Oria, Veronica, Conti, Francesca, Di Cesare, Silvia, Fousteri, Georgia, Carotti, Adriano, Giamberti, Alessandro, Poliani, Pietro Luigi, Notarangelo, Luigi D., Cancrini, Caterina, Villa, Anna, Bosticardo, Marita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436073/
https://www.ncbi.nlm.nih.gov/pubmed/30949166
http://dx.doi.org/10.3389/fimmu.2019.00447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436073/
https://www.ncbi.nlm.nih.gov/pubmed/30949166
http://dx.doi.org/10.3389/fimmu.2019.00447

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