Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis Rates

Faithful DNA replication is challenged by stalling of replication forks during S phase. Replication stress is further increased in cancer cells or in response to genotoxic insults. Using live single-cell image analysis, we found that CDK2 activity fluctuates throughout an unperturbed S phase. We sho...

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Detalles Bibliográficos
Autores principales: Daigh, Leighton H., Liu, Chad, Chung, Mingyu, Cimprich, Karlene A., Meyer, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436092/
https://www.ncbi.nlm.nih.gov/pubmed/29909278
http://dx.doi.org/10.1016/j.cels.2018.05.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436092/
https://www.ncbi.nlm.nih.gov/pubmed/29909278
http://dx.doi.org/10.1016/j.cels.2018.05.011

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