Receptor selectivity between the G proteins Gα(12) and Gα(13) is defined by a single leucine-to-isoleucine variation

Despite recent advances in structural definition of GPCR–G protein complexes, the basis of receptor selectivity between G proteins remains unclear. The Gα(12) and Gα(13) subtypes together form the least studied group of heterotrimeric G proteins. G protein–coupled receptor 35 (GPR35) has been sugges...

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Detalles Bibliográficos
Autores principales: Mackenzie, Amanda E., Quon, Tezz, Lin, Li-Chiung, Hauser, Alexander S., Jenkins, Laura, Inoue, Asuka, Tobin, Andrew B., Gloriam, David E., Hudson, Brian D., Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436656/
https://www.ncbi.nlm.nih.gov/pubmed/30601679
http://dx.doi.org/10.1096/fj.201801956R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436656/
https://www.ncbi.nlm.nih.gov/pubmed/30601679
http://dx.doi.org/10.1096/fj.201801956R

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