A geographically matched control population efficiently limits the number of candidate disease-causing variants in an unbiased whole-genome analysis

Whole-genome sequencing is a promising approach for human autosomal dominant disease studies. However, the vast number of genetic variants observed by this method constitutes a challenge when trying to identify the causal variants. This is often handled by restricting disease studies to the most dam...

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Detalles Bibliográficos
Autores principales: Rentoft, Matilda, Svensson, Daniel, Sjödin, Andreas, Olason, Pall I., Sjöström, Olle, Nylander, Carin, Osterman, Pia, Sjögren, Rickard, Netotea, Sergiu, Wibom, Carl, Cederquist, Kristina, Chabes, Andrei, Trygg, Johan, Melin, Beatrice S., Johansson, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436687/
https://www.ncbi.nlm.nih.gov/pubmed/30917156
http://dx.doi.org/10.1371/journal.pone.0213350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436687/
https://www.ncbi.nlm.nih.gov/pubmed/30917156
http://dx.doi.org/10.1371/journal.pone.0213350

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