Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators

Allosteric ligands bind to receptors at sites that are distinct from those endogenous agonists and orthosteric pharmacological agents interact with. Both an allosteric and orthosteric ligand bind simultaneously to the receptor to form a ternary complex, where each ligand influences binding affinity...

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Detalles Bibliográficos
Autores principales: Jakubík, Jan, Randáková, Alena, El-Fakahany, Esam E., Doležal, Vladimír
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436737/
https://www.ncbi.nlm.nih.gov/pubmed/30917186
http://dx.doi.org/10.1371/journal.pone.0214255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436737/
https://www.ncbi.nlm.nih.gov/pubmed/30917186
http://dx.doi.org/10.1371/journal.pone.0214255

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