Pharmacological and molecular dynamics analyses of differences in inhibitor binding to human and nematode PDE4: Implications for management of parasitic nematodes

Novel chemical controls are needed that selectively target human, animal, and plant parasitic nematodes with reduced adverse effects on the host or the environment. We hypothesize that the phosphodiesterase (PDE) enzyme family represents a potential target for development of novel nematicides and an...

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Detalles Bibliográficos
Autores principales: Schuster, Kevin D., Mohammadi, Mohammadjavad, Cahill, Karyn B., Matte, Suzanne L., Maillet, Alexis D., Vashisth, Harish, Cote, Rick H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436744/
https://www.ncbi.nlm.nih.gov/pubmed/30917179
http://dx.doi.org/10.1371/journal.pone.0214554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436744/
https://www.ncbi.nlm.nih.gov/pubmed/30917179
http://dx.doi.org/10.1371/journal.pone.0214554

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