Cellular response to small molecules that selectively stall protein synthesis by the ribosome

Identifying small molecules that inhibit protein synthesis by selectively stalling the ribosome constitutes a new strategy for therapeutic development. Compounds that inhibit the translation of PCSK9, a major regulator of low-density lipoprotein cholesterol, have been identified that reduce LDL chol...

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Detalles Bibliográficos
Autores principales: Liaud, Nadège, Horlbeck, Max A., Gilbert, Luke A., Gjoni, Ketrin, Weissman, Jonathan S., Cate, Jamie H. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436758/
https://www.ncbi.nlm.nih.gov/pubmed/30875366
http://dx.doi.org/10.1371/journal.pgen.1008057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436758/
https://www.ncbi.nlm.nih.gov/pubmed/30875366
http://dx.doi.org/10.1371/journal.pgen.1008057

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